Orangeburg - Santee Extended Stay
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Hampton Inn & Suites - Orangeburg

New hotel (2015). 100% non-smoking. Free WiFi. Options include large 1-room suites with sofabed & kitchenette. Free breakfast. Onsite: fitness room, convenience store, guest laundry & outdoor swimming pool & BBQ.
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Holiday Inn - Santee

Full-service hotel. Renovated in 2015. Executive rooms & suites available.

Holiday Inn Express & Suites - Orangeburg

Renovated in 2015. 100% non-smoking. 1 & 2-room suites available.